Annual report [Section 13 and 15(d), not S-K Item 405]

Fair Value Measurements - Narrative (Details)

v3.25.1
Fair Value Measurements - Narrative (Details)
 3 Months Ended 12 Months Ended
Mar. 28, 2024
USD ($)
shares
Dec. 31, 2024
USD ($)
$ / shares
Dec. 31, 2022
USD ($)
Dec. 31, 2024
USD ($)
$ / shares
Dec. 31, 2023
USD ($)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Goodwill impairment       $ 0 $ 3,907,000
Change in fair value       79,300,000  
Change in fair value of warrant liability       (121,611,000) 0
AVTX-501          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Maximum aggregate milestone payment     $ 20,000,000    
Derivative liability   $ 0   0  
AVTX-007          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Initial valuation of warrant liability       400,000  
AVTX-007 | Milestone One          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Maximum aggregate milestone payment     6,250,000    
AVTX-007 | Milestone Two          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Maximum aggregate milestone payment     67,500,000    
AVTX-611          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Maximum aggregate milestone payment     20,000,000    
Warrant liability          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Change in fair value       121,600,000  
Derivative liability          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Change in fair value       2,900,000  
Derivative liability | AVTX-501          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Initial valuation of warrant liability     $ 3,500,000    
Derivative liability | AVTX-501 | Measurement Input, Probability Of Success          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Derivative liability, measurement input     0.01    
Derivative liability | AVTX-007          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Initial valuation of warrant liability     $ 1,300,000    
Contingent consideration   8,500,000   8,500,000  
Derivative liability | AVTX-007 | Measurement Input, Probability Of Success          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Derivative liability, measurement input     0.17    
Derivative liability | AVTX-007 | Measurement Input, Expected Term          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Derivative liability, measurement input term     6 years    
Derivative liability | AVTX-007 | Measurement Input, Sales Forecast Peak          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Change in fair value of warrant liability     $ 1,800,000,000    
Derivative liability | AVTX-501 And AVTX-007          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Initial valuation of warrant liability     4,800,000    
Derivative liability | ES          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Initial valuation of warrant liability     5,000,000    
Level 3          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Initial valuation of warrant liability       194,901,000  
Change in fair value       (118,681,000) 720,000
Settlement of warrant liability       (73,290,000)  
Contingent consideration   8,480,000 4,830,000 8,480,000 5,550,000
Level 3 | Warrant liability          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Initial valuation of warrant liability       194,901,000  
Change in fair value       (121,611,000)  
Settlement of warrant liability   (73,300,000)   (73,290,000)  
Contingent consideration   0   0 0
Level 3 | Derivative liability          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Initial valuation of warrant liability       0  
Change in fair value       2,930,000 720,000
Settlement of warrant liability       0  
Contingent consideration   $ 8,480,000 $ 4,830,000 $ 8,480,000 $ 5,550,000
Warrant liability | Level 3          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Exercise price per share (in dollars per share) | $ / shares   $ 5.796933   $ 5.796933  
Private Placement | Warrant liability          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Number of shares issued (in shares) | shares 11,967,526        
Potential proceeds from future exercise of warrants   $ 0   $ 0  
Warrant liability   $ 0   0  
Private Placement | Series C Preferred Stock          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Net proceeds $ 115,600,000     $ 115,600,000  
Series C Preferred Stock | Private Placement          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Number of shares issued (in shares) | shares 19,946