Quarterly report pursuant to Section 13 or 15(d)

Stock-Based Compensation

v3.24.2.u1
Stock-Based Compensation
6 Months Ended
Jun. 30, 2024
Share-Based Payment Arrangement [Abstract]  
Stock-Based Compensation Stock-Based Compensation
2016 Equity Incentive Plan

In April 2016, our board of directors adopted the 2016 Equity Incentive Plan, which was approved by our stockholders in May 2016 and which was subsequently amended and restated in May 2018 and August 2019 with the approval of our board of directors and our stockholders (the “2016 Third Amended Plan”). In June 2024, our board of directors approved a fourth amended and restated equity incentive plan, which is subject to Company stockholder approval. At the time of the filing of this Quarterly Report on Form 10-Q, the fourth amended and restated equity incentive plan has not been approved by our stockholders, which is being sought at the Company’s annual meeting of stockholders on August 13, 2024. As such, the 2016 Third Amended Plan continues to govern the share reserves disclosed below. During the term of the 2016 Third Amended Plan, the share reserve will automatically increase on the first trading day in January of each calendar year ending on (and including) January 1, 2026, by an amount equal to 4% of the total number of outstanding shares of common stock of the Company on the last trading day in December of the prior calendar year. On January 1, 2024, pursuant to the terms of the 2016 Third Amended Plan, an additional 32,070 shares were made available for issuance. As of June 30, 2024, there were 33,099 shares available for future issuance under the 2016 Third Amended Plan.

Option grants expire after ten years. Employee options typically vest over four years. Employees typically receive a new hire option grant, as well as an annual grant in the first or second quarter of each year. Options granted to directors typically vest either immediately or over a period of one or three years. Directors may elect to receive stock options in lieu of board compensation, which vest immediately. For stock options granted to employees and non-employee directors, the estimated grant date fair market value of the Company’s stock-based awards is amortized ratably over the individuals’ service periods, which is the period in which the awards vest. Stock-based compensation expense includes expense related to stock options and employee stock purchase plan shares. The amount of stock-based compensation expense recognized for the three and six months ended June 30, 2024 and 2023 was as follows (in thousands): 

  Three Months Ended June 30, Six Months Ended June 30,
  2024 2023 2024 2023
Research and development $ 219  $ 331  $ 488  $ 658 
General and administrative 252  562  612  1,090 
Total stock-based compensation $ 471  $ 893  $ 1,100  $ 1,748 

Stock options with service-based vesting conditions

The Company has granted options that contain service-based vesting conditions. The compensation cost for these options is recognized on a straight-line basis over the vesting periods. A summary of option activity for the six months ended June 30, 2024 is as follows:
  Options Outstanding
  Number of shares Weighted average exercise price per share Weighted average grant date fair value per share Weighted average remaining contractual term (in years)
Balance at December 31, 2023 7,211  $ 3,191.97  $ 1,930.00  8.3
Granted 150,000  $ 13.43  $ 10.94 
Forfeited (13) $ 660.00  $ 472.94 
Expired (202) $ 10,162.23  $ 6,254.04 
Balance at June 30, 2024 156,996  $ 146.25  $ 91.25  9.9
Exercisable at June 30, 2024 5,433  $ 3,462.88  $ 2,050.59  7.7

On June 24, 2024, the Company granted its newly appointed Chief Legal Officer options with service-based vesting conditions to purchase 150,000 shares of common stock with an exercise price of $13.43 as an inducement option grant pursuant to Nasdaq Listing Rule 5635(c)(4).

The aggregate intrinsic value of stock options is calculated as the difference between the exercise price of the stock options and the fair value of the Company’s common stock for those stock options that had exercise prices lower than the fair value of the Company’s common stock. As of June 30, 2024, the aggregate intrinsic value of options outstanding was minimal. There were 2,119 options that vested during the six months ended June 30, 2024 with a weighted average exercise price of $1,067.14 per share. The total grant date fair value of shares which vested during the six months ended June 30, 2024 was $1.6 million.

The Company recognized stock-based compensation expense of $0.5 million and $1.1 million related to stock options with service-based vesting conditions for the three and six months ended June 30, 2024. At June 30, 2024, there was $3.4 million of total unrecognized compensation cost related to unvested service-based vesting condition awards. The unrecognized compensation cost is expected to be recognized over a weighted-average period of 2.6 years.

Subsequently, on July 15, 2024, the Company granted its newly appointed Chief Medical Officer options with service-based vesting conditions to purchase 234,000 shares of common stock with an exercise price of $12.65 as an inducement option grant pursuant to Nasdaq Listing Rule 5635(c)(4).

Stock-based compensation assumptions

The following table presents the assumptions used to compute stock-based compensation for stock options with service-based vesting conditions granted under the Black-Scholes valuation model for the six months ended June 30, 2024.

Service-based options  
Expected term of option (in years)  
6.25
Expected stock price volatility  
99.7%
Risk-free interest rate  
4.26%
Expected annual dividend yield   0%

As of June 30, 2024, there were no outstanding stock options that contained market-based vesting conditions.

Employee Stock Purchase Plan
On April 5, 2016, the Company’s board of directors approved the 2016 Employee Stock Purchase Plan (the “ESPP”). The ESPP was approved by the Company’s stockholders and became effective on May 18, 2016 (the “ESPP Effective Date”). In June 2024, our board of directors approved an amended and restated employee stock purchase plan, which is subject to the Company’s stockholder approval. At the time of the filing of this Quarterly Report on Form 10-Q, the amended and restated employee stock purchase plan has not been approved by our stockholders, which is being sought at the Company’s annual meeting of stockholders on August 13, 2024. As such, the 2016 Employee Stock Purchase Plan continues to govern the share reserves disclosed below.

Under the ESPP, eligible employees can purchase common stock through accumulated payroll deductions at such times as are established by the administrator. The ESPP is administered by the compensation committee of the Company’s board of directors. Under the ESPP, eligible employees may purchase stock at 85% of the lower of the fair market value of a share of the Company’s common stock (i) on the first day of an offering period or (ii) on the purchase date. Eligible employees may contribute up to 15% of their earnings during the offering period. The Company’s board of directors may establish a maximum number of shares of the Company’s common stock that may be purchased by any participant, or all participants in the aggregate, during each offering or offering period. Under the ESPP, a participant may not accrue rights to purchase more than $25,000 of the fair market value of the Company’s common stock for each calendar year in which such right is outstanding.

The Company initially reserved and authorized up to 174 shares of common stock for issuance under the ESPP. On January 1 of each calendar year, the aggregate number of shares that may be issued under the ESPP automatically increases by a number equal to the lesser of (i) 1% of the total number of shares of the Company’s capital stock outstanding on December 31 of the preceding calendar year, (ii) 174 shares of the Company’s common stock, or (iii) a number of shares of the Company’s common stock as determined by the Company’s board of directors or compensation committee. On January 1, 2024, the number of shares available for issuance under the ESPP increased by 174. As of June 30, 2024, 958 shares remained available for issuance.

In accordance with the guidance in ASC 718-50, Employee Share Purchase Plans, the ability to purchase shares of the Company’s common stock at the lower of the offering date price or the purchase date price represents an option and, therefore, the ESPP is a compensatory plan under this guidance. Accordingly, stock-based compensation expense is determined based on the option’s grant-date fair value and is recognized over the requisite service period of the option. The Company used the Black-Scholes valuation model and recognized minimal stock-based compensation expense for the three and six months ended June 30, 2024.