Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies (Details)

v3.24.2.u1
Commitments and Contingencies (Details)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Mar. 28, 2024
USD ($)
Oct. 27, 2023
USD ($)
Apr. 30, 2024
USD ($)
Jul. 31, 2019
USD ($)
Mar. 31, 2020
USD ($)
milestone
Jun. 30, 2024
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2018
unit
$ / shares
Mar. 27, 2024
USD ($)
Dec. 31, 2023
USD ($)
Jun. 30, 2021
USD ($)
Jun. 21, 2021
USD ($)
Jun. 09, 2021
USD ($)
May 28, 2021
USD ($)
Mar. 25, 2021
USD ($)
Feb. 03, 2020
USD ($)
Other Commitments [Line Items]                                
Contingent consideration           $ 5,000,000       $ 0            
Payment received       $ 2,000,000                        
Period after public launch to terminate agreement       3 years                        
Percentage of net present value of royalty payments       75.00%                        
Aevi                                
Other Commitments [Line Items]                                
Milestone payment           0                    
AlmataBio Transaction                                
Other Commitments [Line Items]                                
Payments to acquire productive assets $ 7,500,000   $ 7,500,000     7,500,000                    
Milestone payment due upon first patient dosed in a Phase 2 trial           5,000,000                    
Aevi                                
Other Commitments [Line Items]                                
Number of milestones | milestone         2                      
Milestone payment due upon first patient dosed in a Phase 2 trial         $ 6,500,000                      
Milestone One | AlmataBio Transaction                                
Other Commitments [Line Items]                                
Milestone payment due upon first patient dosed in a Phase 2 trial 5,000,000                              
Milestone One | Aevi                                
Other Commitments [Line Items]                                
Milestone payment due upon first patient dosed in a Phase 2 trial                               $ 2,000,000.0
Milestone Two | AlmataBio Transaction                                
Other Commitments [Line Items]                                
Milestone payment due upon first patient dosed in a Phase 2 trial $ 15,000,000                              
Milestone Two | Aevi                                
Other Commitments [Line Items]                                
Milestone payment due upon first patient dosed in a Phase 2 trial                               4,500,000
Milestone Two | AVTX-009                                
Other Commitments [Line Items]                                
Contingent consideration           5,000,000                    
Lilly License Agreement | AVTX-009 Lilly License Agreement                                
Other Commitments [Line Items]                                
Milestone payments                 $ 70,000,000              
Maximum aggregate milestone payment                 $ 650,000,000              
Kyowa Kirin Co., Ltd. (KKC) | AVTX-002 KKC License Agreement                                
Other Commitments [Line Items]                                
Upfront license fee                             $ 10,000,000  
Research and development expense           0                    
Cumulative expense recognized to date           0                    
Kyowa Kirin Co., Ltd. (KKC) | AVTX-002 KKC License Agreement | Milestone One                                
Other Commitments [Line Items]                                
Maximum aggregate milestone payment                             112,500,000  
Kyowa Kirin Co., Ltd. (KKC) | AVTX-002 KKC License Agreement | Milestone Two                                
Other Commitments [Line Items]                                
Maximum aggregate milestone payment                             $ 75,000,000  
CHOP License Agreement | AVTX-002 KKC License Agreement                                
Other Commitments [Line Items]                                
Maximum aggregate milestone payment                               900,000
Upfront license fee                               500,000
Payments for legal settlements             $ 1,000,000                  
License fee                               $ 200,000
Sanford Burnham Prebys Medical Discovery Institute | AVTX-008 Sanford Burnham Prebys License Agreement                                
Other Commitments [Line Items]                                
Upfront license fee                       $ 400,000        
Research and development expense           0                    
Cumulative expense recognized to date           0                    
License fee                     $ 100,000 40,000        
Patent costs                       500,000        
Sanford Burnham Prebys Medical Discovery Institute | AVTX-008 Sanford Burnham Prebys License Agreement | Milestone One                                
Other Commitments [Line Items]                                
Maximum aggregate milestone payment                       24,200,000        
Sanford Burnham Prebys Medical Discovery Institute | AVTX-008 Sanford Burnham Prebys License Agreement | Milestone Two                                
Other Commitments [Line Items]                                
Maximum aggregate milestone payment                       $ 50,000,000        
Astellas Pharma, Inc. (Astellas) | AVTX-006 Astellas License Agreement                                
Other Commitments [Line Items]                                
Maximum aggregate milestone payment           5,500,000                    
Upfront license fee           500,000                    
Research and development expense           0                    
Cumulative expense recognized to date           500,000                    
Alto | AVTX-301 Out-License                                
Other Commitments [Line Items]                                
Maximum proceeds from milestones                           $ 18,600,000    
Revenue recognized from milestones to date           0                    
ES | AVTX-406 License Assignment                                
Other Commitments [Line Items]                                
Revenue recognized from milestones to date           $ 0                    
ES | Milestone One | AVTX-406 License Assignment                                
Other Commitments [Line Items]                                
Maximum proceeds from milestones                         $ 6,000,000      
ES | Milestone Two | AVTX-406 License Assignment                                
Other Commitments [Line Items]                                
Maximum proceeds from milestones                         $ 20,000,000      
AUG Therapeutics, LLC | Purchase Agreement | AVTX-800 Series Asset Sale                                
Other Commitments [Line Items]                                
Upfront payment paid   $ 200,000                            
Asset acquisition consideration transferred, liabilities   $ 400,000                            
Contingent milestone upfront payment percentage   0.20                            
Contingent milestone payment   $ 15,000,000                            
Maximum potential payments   $ 45,000,000                            
TRIS Pharma | Karbinal Agreement                                
Other Commitments [Line Items]                                
Minimum quantity required | unit               70,000                
Make whole payment per unit (in dollars per share) | $ / shares               $ 30