Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Convertible Preferred Stock and Stockholder's Equity (Deficit)

Consolidated Statements of Convertible Preferred Stock and Stockholder's Equity (Deficit) - USD ($)	Total	Common stock	Additional paid in capital	Contingently Issuable Common Stock	Accumulated deficit	Redeemable Convertible Preferred Stock	Common stock
Balance at the beginning (in shares) at Dec. 31, 2014						99,139,637
Balance at the beginning at Dec. 31, 2014						$ 28,345,531
Increase (Decrease) in Temporary Equity [Roll Forward]
Issuance of common stock for conversion of preferred stock upon closing of initial public offering (in shares)						(99,139,637)
Issuance of common stock for conversion of preferred stock upon closing of initial public offering						$ (28,345,531)
Balance at the end (in shares) at Dec. 31, 2015						0
Balance at the end at Dec. 31, 2015						$ 0
Balance at the beginning (in shares) at Dec. 31, 2014		649,721
Balance at the beginning at Dec. 31, 2014	$ (26,330,664)	$ 650	$ 16,742,063		$ (43,073,377)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of stock (in shares)		4,020,000
Issuance of stock	21,165,589	$ 4,020	21,161,569
Issuance of common stock for conversion of preferred stock (in shares)							3,980,422
Issuance of common stock for conversion of preferred stock	28,344,157		28,340,177				$ 3,980
Issuance of shares in acquisition of TRx	0
Contingently issuable stock in acquisition of TRx	0
Stock-based compensation	394,748		394,748
Net income (loss)	(10,490,103)				(10,490,103)
Balance at the end (in shares) at Dec. 31, 2015		8,650,143
Balance at the end at Dec. 31, 2015	13,083,727	$ 8,650	66,638,557		(53,563,480)
Balance at the end (in shares) at Dec. 31, 2016						0
Balance at the end at Dec. 31, 2016						$ 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of stock (in shares)		763,998
Issuance of stock	1,899,987	$ 764	1,899,223
Issuance of shares in acquisition of TRx	0
Contingently issuable stock in acquisition of TRx	0
Shares purchased through employee stock purchase plan	0		(20)				$ 20
Shares purchased through employee stock purchase plan (in shares)							20,000
Stock-based compensation	1,694,891		1,694,891
Net income (loss)	(16,471,603)				(16,471,603)
Balance at the end (in shares) at Dec. 31, 2016		9,434,141
Balance at the end at Dec. 31, 2016	207,002	$ 9,434	70,232,651		(70,035,083)
Increase (Decrease) in Temporary Equity [Roll Forward]
Issuance of preferred and common stock to Armistice Capital, net of offering costs						4
Conversion of Armistice Capital preferred to common stock						$ (4)
Balance at the end (in shares) at Dec. 31, 2017						0
Balance at the end at Dec. 31, 2017						$ 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of stock (in shares)		2,301,598
Issuance of stock	1,502,593	$ 2,302	1,500,291
Issuance of common stock to Armistice Capital (in shares)		2,345,714
Issuance of preferred and common stock to Armistice Capital, net of offering costs	4,561,654	$ 2,346	4,559,308
Issuance of common stock for conversion of preferred stock (in shares)							11,940,000
Issuance of common stock for conversion of preferred stock	4		(11,936)				$ 11,940
Issuance of shares in acquistion of TRx (in shares)		5,184,920
Issuance of shares in acquisition of TRx	5,858,955	$ 5,185	5,853,770
Contingently issuable stock in acquisition of TRx	2,655,464			$ 2,655,464
Shares purchased through employee stock purchase plan	46,861	$ 61	46,800
Shares purchased through employee stock purchase plan (in shares)		60,616
Stock-based compensation	1,157,252		1,157,252
Net income (loss)	11,869,823				11,869,823
Balance at the end (in shares) at Dec. 31, 2017		31,266,989
Balance at the end at Dec. 31, 2017	$ 27,859,608	$ 31,268	$ 83,338,136	$ 2,655,464	$ (58,165,260)