Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Changes in Stockholders' Equity

Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands	Total	Underwritten Public Offering	ATM Agreement	Common stock	Common stock Underwritten Public Offering	Common stock ATM Agreement	Preferred Stock	Additional paid-in capital	Additional paid-in capital Underwritten Public Offering	Additional paid-in capital ATM Agreement	Accumulated deficit
Balance at the beginning (in shares) at Dec. 31, 2019				44,384,222			2,857,143
Balance at the beginning at Dec. 31, 2019	$ 20,996			$ 45			$ 3	$ 135,238			$ (114,290)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Conversion of preferred stock to common stock (in shares)				8,000,000			(1,600,000)
Conversion of preferred stock to common stock	0			$ 8			$ (2)	(6)
Issuance of shares related to Aevi Merger (in shares)				3,893,361
Issuance of shares related to Aevi Merger	15,496			$ 4				15,492
Issuance of shares pursuant to registered direct offering, net of offering costs (in shares)				1,306,282
Issuance of shares pursuant to registered direct offering, net	5,136			$ 1				5,135
Issuance of shares pursuant to common stock private placement, net (in shares)				1,951,219
Issuance of shares pursuant to common stock private placement, net	3,888			$ 2				3,886
Issuance of shares of common stock (in shares)				15,180,000
Issuance of shares of common stock	35,428			$ 15				35,413
Exercise of stock options and warrants (in shares)				75,239
Exercise of stock options and warrants	114							114
Restricted stock units withheld for taxes (in shares)				(35,279)
Restricted stock units withheld for taxes	(94)							(94)
Shares purchased through employee stock purchase plan (in shares)				137,416
Shares purchased through employee stock purchase plan	312							312
Restricted stock units vested during the period (in shares)				111,667
Stock-based compensation	6,786							6,786
Net loss	(63,500)										(63,500)
Balance at the end (in shares) at Dec. 31, 2020				75,004,127			1,257,143
Balance at the end at Dec. 31, 2020	24,562			$ 75			$ 1	202,276			(177,790)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Conversion of preferred stock to common stock (in shares)				6,285,715			(1,257,143)
Conversion of preferred stock to common stock	1			$ 7			$ (1)	(5)
Issuance of shares of common stock and pre-funded warrants in underwritten public offering, net (in shares)				13,971,889
Issuance of shares of common stock and pre-funded warrants in underwritten public offering, net	37,653			$ 14				37,639
Issuance of shares of common stock (in shares)					14,308,878	2,000,000
Issuance of shares of common stock		$ 29,046	$ 5,230		$ 14	$ 2			$ 29,032	$ 5,228
Issuance of equity classified warrants related to venture debt financing agreement	861							861
Exercise of stock options (in shares)				580,617
Exercise of stock options	1,567			$ 1				1,566
Exercise of pre-funded warrants (in shares)				308,697
Shares purchased through employee stock purchase plan (in shares)				189,697
Shares purchased through employee stock purchase plan	366							366
Restricted stock units vested during the period (in shares)				144,583
Stock-based compensation	8,172							8,172
Net loss	(84,376)										(84,376)
Balance at the end (in shares) at Dec. 31, 2021				112,794,203			0
Balance at the end at Dec. 31, 2021	$ 23,082			$ 113			$ 0	$ 285,135			$ (262,166)