Quarterly report pursuant to Section 13 or 15(d)

Capital Structure - Common Stock (Details)

Capital Structure - Common Stock (Details)							3 Months Ended			12 Months Ended
Capital Structure - Common Stock (Details)	Mar. 08, 2019 USD ($) $ / shares shares	Dec. 27, 2018 USD ($) $ / shares shares	Sep. 25, 2018 shares	Sep. 24, 2018 $ / shares shares	Aug. 17, 2018 USD ($) $ / shares shares	Nov. 17, 2017 USD ($) shares	Mar. 31, 2019 USD ($) Vote class_of_stock $ / shares shares	Dec. 31, 2018 USD ($) $ / shares shares	Mar. 31, 2018 USD ($)	Dec. 31, 2018 USD ($) $ / shares shares	Dec. 31, 2017 $ / shares shares	Oct. 31, 2015 shares	Dec. 31, 2014 shares
Common Stock
Number of classes of stock authorized to issue \| class_of_stock							2
Number of shares of capital stock authorized to issue (in shares)							205,000,000
Common stock, shares authorized (in shares)							200,000,000	200,000,000		200,000,000
Preferred stock, shares authorized (in shares)							5,000,000	5,000,000		5,000,000
Common stock, par value (in dollars per share) \| $ / shares				$ 0.001	$ 0.001		$ 0.001	$ 0.001		$ 0.001
Preferred stock, par value per share (in dollars per share) \| $ / shares							$ 0.001	$ 0.001		$ 0.001
Proceeds from issuance of common stock \| $							$ 8,975,960		$ 0
Common stock
Common Stock
Number of shares available under warrant (in shares)												22,328
Issuance of stock (in shares)							1,818,182
Common Stock
Common Stock
Number of votes per share \| Vote							1
Number of preemptive, conversion or subscription rights \| class_of_stock							0
Number of redemption or sinking fund provisions \| class_of_stock							0
Series B Preferred Stock \| Preferred Stock
Common Stock
Preferred stock conversion ratio		5					5	5
Number of shares available under warrant (in shares)													625,208
Private Placement
Common Stock
Number of shares available under warrant (in shares)											14,285,714
Exercise price per share (in dollars per share) \| $ / shares											$ 0.40
Proceeds from warrant exercises \| $								$ 5,700,000		$ 5,700,000
Sale of stock, price (in dollars per share) \| $ / shares					$ 3.91
Proceeds from issuance or sale of equity \| $					$ 3,900,000
Private Placement \| Common stock
Common Stock
Issuance of stock (in shares)					1,000,000
Private Placement \| Series B Preferred Stock \| Preferred Stock
Common Stock
Preferred stock, shares authorized (in shares)		2,857,143						2,857,143		2,857,143
Preferred stock, par value per share (in dollars per share) \| $ / shares		$ 2.00
Bought Deal
Common Stock
Sale of stock, price (in dollars per share) \| $ / shares	$ 5.50
Proceeds from issuance of common stock \| $	$ 10,000,000
Net proceeds from sale of stock \| $	$ 9,000,000
Number of shares issued in transaction (in shares)	1,818,182
Bought Deal \| Armistice
Common Stock
Number of shares issued in transaction (in shares)	363,637
TRx
Common Stock
Unregistered shares of common stock issued or issuable as part of acquisition \| $						$ 8,100,000
Shares issued upon closing (in shares)						5,184,920
Contingent shares issuable as part of acquisition (in shares)						2,349,968
Ichorion
Common Stock
Consideration issued (in shares)			5,800,000	5,800,000
Incentive Warrants
Common Stock
Number of shares available under warrant (in shares)		4,000,000
Exercise price per share (in dollars per share) \| $ / shares		$ 12.50
Expected life		5 years 6 months
Distribution adjustment \| $		$ 1,700,000