Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Changes in Stockholder's Equity

Consolidated Statements of Changes in Stockholder's Equity - USD ($)	Total	Common stock	Additional paid in capital	Contingently Issuable Common Stock	Accumulated deficit	Common stock	Redeemable Convertible Preferred Stock Preferred Stock
Balance at the beginning (in shares) at Dec. 31, 2017		31,266,989					0
Balance at the beginning at Dec. 31, 2017	$ 27,859,608	$ 31,268	$ 83,338,136	$ 2,655,464	$ (58,165,260)		$ 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of contingently issuable shares in acquisition of TRX (in shares)		2,349,968
Issuance of contingently issuable shares in acquisition of TRx	0	$ 2,350	2,653,114	(2,655,464)
Issuance of shares pursuant to common stock private placement, net of offering costs (in shares)		1,000,000
Issuance of shares pursuant to common stock private placement, net of offering costs	3,857,106	$ 1,000	3,856,106
Issuance of shares in acquisition of Ichorion assets (in shares)		5,774,464
Issuance of shares in acquisition of Ichorion assets	19,971,554	$ 5,774	19,965,780
Issuance of Series B convertible preferred stock upon warrant exercise, net of offering costs (in shares)							2,857,143
Issuance of Series B convertible preferred stock upon warrant exercise, net of offering costs	5,685,038		5,682,181				$ 2,857
Exercise of stock options and warrants (in shares)		370,361
Exercise of stock options and warrants	1,083,953	$ 370	1,083,583
Shares purchased through employee stock purchase plan (in shares)		42,407
Shares purchased through employee stock purchase plan	72,236	$ 42	72,194
Stock-based compensation	2,431,063		2,431,063
Net loss	(40,052,810)				(40,052,810)
Balance at the end (in shares) at Dec. 31, 2018		40,804,189					2,857,143
Balance at the end at Dec. 31, 2018	20,907,748	$ 40,804	119,082,157	0	(98,218,070)		$ 2,857
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of shares pursuant to common stock private placement, net of offering costs (in shares)						1,200,000
Issuance of shares pursuant to common stock private placement, net of offering costs	3,708,602		3,707,402			$ 1,200
Exercise of stock options and warrants (in shares)		323,177
Exercise of stock options and warrants	836,188	$ 323	835,865
Shares purchased through employee stock purchase plan (in shares)						73,143
Shares purchased through employee stock purchase plan	210,777		210,704			$ 73
Stock-based compensation	2,462,796		2,462,796
Net loss	(16,072,547)				(16,072,547)
Issuance of shares of common stock in underwritten public offering, net of offering costs (in shares)		1,818,182
Issuance of shares of common stock in underwritten public offering, net of offering costs	8,975,960	$ 1,818	8,974,142
Restricted Stock Units vested during the period (in shares)						172,500
Restricted Stock Units vested during the period	0	173	(173)
Restricted Stock Units withheld for taxes (in shares)						(6,969)
Restricted Stock Units withheld for taxes	(33,959)	$ (7)	(33,952)
Balance at the end (in shares) at Dec. 31, 2019		44,384,222					2,857,143
Balance at the end at Dec. 31, 2019	$ 20,995,565	$ 44,384	$ 135,238,941	$ 0	$ (114,290,617)		$ 2,857